Cardiac Fibroblasts Expressing VEGF Prevents Cardiac Injury in Rats
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چکیده
منابع مشابه
Targeted Ablation of Periostin-Expressing Activated Fibroblasts Prevents Adverse Cardiac Remodeling in Mice.
RATIONALE Activated cardiac fibroblasts (CF) are crucial players in the cardiac damage response; excess fibrosis, however, may result in myocardial stiffening and heart failure development. Inhibition of activated CF has been suggested as a therapeutic strategy in cardiac disease, but whether this truly improves cardiac function is unclear. OBJECTIVE To study the effect of CF ablation on card...
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To evaluate the effects of hypertension on cardiac hypertrophy, on myocardial structure, and on ventricular arrhythmias, 27 3-month-old spontaneously hypertensive rats were treated with enalapril (10 mg/kg) daily for 11 months and compared with 26 untreated control rats. Systolic arterial pressure was significantly decreased in treated rats, and at the end of the experiment, it was 199 +/- 3 mm...
متن کاملAkt activation preserves cardiac function and prevents injury after transient cardiac ischemia in vivo.
BACKGROUND The serine-threonine kinase Akt is activated by several ligand-receptor systems previously shown to be cardioprotective. Akt activation reduces cardiomyocyte apoptosis in models of transient ischemia. Its role in cardiac dysfunction or infarction, however, remains unclear. METHODS AND RESULTS We examined the effects of a constitutively active Akt mutant (myr-Akt) in a rat model of ...
متن کاملWnt1/bcatenin injury response activates the epicardium and cardiac fibroblasts to promote cardiac repair
Jinzhu Duan, Costin Gherghe, Dianxin Liu, Eric Hamlett, Luxman Srikantha, Laurel Rodgers, Jenna N Regan, Mauricio Rojas, Monte Willis, Andrew Leask, Mark Majesky and Arjun Deb* Department of Medicine, McAllister Heart Institute and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA, Department of Cell and Molecular Physiology, McAllister Heart Institute a...
متن کاملWnt1/βcatenin injury response activates the epicardium and cardiac fibroblasts to promote cardiac repair.
Wnts are required for cardiogenesis but the role of specific Wnts in cardiac repair remains unknown. In this report, we show that a dynamic Wnt1/βcatenin injury response activates the epicardium and cardiac fibroblasts to promote cardiac repair. Acute ischaemic cardiac injury upregulates Wnt1 that is initially expressed in the epicardium and subsequently by cardiac fibroblasts in the region of ...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2007
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.21.6.a857-b